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apalutamide will decrease the level or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medicines which might be CYP2C19 substrates may result in decrease publicity to these prescription drugs.conivaptan will boost the stage or impact of d